Biology of Langerhans cells: Selective migration of Langerhans cells into allogeneic and xenogeneic grafts on nude mice

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Biology of Langerhans cells: selective migration of Langerhans cells into allogeneic and xenogeneic grafts on nude mice.

A major question challenging immunobiologists relates to those mechanisms that control the selective movement of cells involved in immune and inflammatory processes at various tissue sites such as the skin. Little is known about those influences that control the selective migration of macrophage-like Langerhans cells (LC) to normal epidermis, where it is uniformly distributed. Mechanistically, ...

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Langerhans Cells in Skin Lesions of Leprosy

Background: Langerhans cells are important in the pathogenesis of leprosy.  A recent study reported that these cells were almost absent in the epidermis overlying lepromatous lesions. Objective: To investigate a possible relationship between the number of Langerhans cells and the histopathologic spectrum of lesions in patients with leprosy. Methods: An immunohistochemical staining for S100 prot...

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Study of Langerhans cells after allogeneic bone marrow transplantation.

We assessed the number of Langerhans cells (LC) before and after bone marrow transplantation (BMT) in 27 patients in order to study the fate and behavior of these dendritic antigen-presenting cells following allogeneic BMT. LC were identified using monoclonal antibody OKT6 on skin biopsies performed on days - 10, 0, 11, 25, 39, 120, and 365. In a control group composed of 15 healthy adults aged...

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Differentiation of Langerhans cells in Langerhans cell histiocytosis.

Langerhans cell histiocytosis (LCH) consists of lesions composed of cells with a dendritic Langerhans cell (LC) phenotype. The clinical course of LCH ranges from spontaneous resolution to a chronic and sometimes lethal disease. We studied 25 patients with various clinical forms of the disease. In bone and chronic lesions, LCH cells had immature phenotype and function. They coexpressed LC antige...

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Effect of glucocorticosteroids on epidermal Langerhans cells

The effects of topical and systemic administration of various glucocorticoids on the density of epidermal Langerhans cells (LC) were studied in guinea pigs. Glucocorticoids, such as betamethasone dipropionate and valerate, caused a marked decrease in LC demonstrable by staining for cell membrane ATPase activity and Ia antigens. By electronmicroscopy, LC also showed morphologic alterations. The ...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1983

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.80.6.1650